Intermittent fasting may not be all its cracked up to be, study finds

Fontana was unconvinced but curious. “I’m a scientist, so I’m always kind of sceptical … unless you do the studies in humans.”

So he did. To test whether intermittent fasting had effects beyond weight loss, he and his team took 50 overweight participants and randomly divided them into two groups.

For six months, one group ate their typical Western diet for four or five days and did vegetable fasting for two or three days. On these days, they didn’t count kilojoules, but ate only non-starchy vegetables dressed with two tablespoons of olive oil and either vinegar or lemon. The second group acted as controls and continued with their usual diet.

The researchers tested for key markers of healthy ageing, including inflammation, insulin sensitivity, mTOR (a protein that helps control important cell functions) and autophagy activation (the process of clearing cellular damage).

After six months, participants in the intermittent fasting group had lost about 8 per cent of their body weight – up to 20 kilograms – and 16 per cent of their body fat. Despite these significant results, they did not reduce inflammation, glucose tolerance or insulin sensitivity.

“Yes, they lose weight. They lose fat. We proved that that’s true, but in terms of metabolic health, inflammation, insulin sensitivity, it doesn’t work at all,” says Fontana, author of upcoming book The Manual of Longevity & Wellbeing: a Three Step Plan.

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“Inflammation is a major factor for ageing, for cancer, for cardiovascular disease … inflammation and insulin sensitivity are the most important factors in ageing biology.”

These findings demonstrate that weight loss by itself is not a guarantee of good health and, Fontana adds, the study confirms that a kilojoule is not a kilojoule. What we eat matters.

“This shortcut of ‘I fast two days a week, I lose weight, and then I’m healthier, and on the five feasting days, I can do whatever I want’ is wrong,” he stresses. “The quality of diet during your non-fasting days and how much you exercise during the non-fasting days is deeply influencing the metabolic response to weight loss.”

Dr Evelyn Parr, a research fellow at Mary MacKillop Institute for Health Research, Australian Catholic University, wonders whether there were high enough levels of inflammation across the cohort to result in a significant change.

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“If intermittent fasting allows someone to have control of their weekly energy intake and adhere to a dietary energy intake which maintains weight, then I am all for it,” Parr says. “If it doesn’t, then I think an alternate strategy like time-restricted eating (TRE) or chronic energy restriction (i.e. smaller restrictions daily) would be a better approach – whatever approach is likely to increase adherence would more likely encourage a greater health benefit.”

It is possible to overdo it, however, as Fontana found. In some participants, the researchers took colon biopsies and found that excessive weight loss via intermediate fasting impaired anti-ageing pathways.

Fontana, who doesn’t fast or count kilojoules but pays attention to the quality of his diet, says the research debunks the idea that if we fast a couple of days a week, we can get away with eating and drinking whatever we want.

“The quality of diet is important, the quality of exercise, the amount of exercise, there are so many other factors in the path of longevity that are part of this puzzle.”

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