Best News Network

Viral transformations in the female genital tract can spell trouble for women’s health

The human papillomavirus (HPV) is a known risk factor for cervical cancer. Researchers at Arizona State University are hoping to better understand the factors leading to persistent HPV infection and the progression to cancer, by studying the complex communities of microbes in the female reproductive tract, known as the vaginal microbiome.

In a new study, Efrem Lim and his colleagues examine an often-overlooked subset of the vaginal microbiome — the viruses. Lim is a researcher with the ASU Biodesign Center for Fundamental and Applied Microbiomics, and an assistant professor at the ASU School of Life Sciences. The research demonstrates that crucial changes in the vast community of viruses or virome may enable persistent HPV infection and progression to cancer. The viral alterations appear to be associated with changes in bacterial composition and genital inflammation.

“Microbes maintain a delicate balance in our body to promote health,” Lim says. “Viruses can tip the scale towards a worse health outcome.”

The research appears in the current issue of the journal mSystems.

Cervical cancer is one of the most common cancers among women. In 2020, more than 600,000 cases and 340,000 deaths were reported worldwide. In addition to infection with the HPV virus, known risk factors for cervical cancer include immunodeficiency, smoking and oral contraceptive use.

Recent studies have explored the relationship of the vaginal microbiome to cervical cancer, though the viral component has often been neglected. Viruses interact with both human cells and the vast profusion of bacteria present in the genital tract. The new study uses next-generation gene sequencing to get a clearer read on the community of viruses present in vaginal microbiome samples from women in the Phoenix, Arizona metropolitan area.

The results highlight an association between genital inflammation and low abundance of the bacterial species Lactobacillus with reduction in virome diversity. Lactobacillus bacteria are known to be important mediators of genital health. Further, conditions conducive to persistent HPV infection were also associated with the abundance of a group of viruses that infect bacteria — known as bacteriophages. The findings further emphasize the importance of studies of the virome and its complex interactions with other constituents of the human microbiome.

Story Source:

Materials provided by Arizona State University. Original written by Richard Harth. Note: Content may be edited for style and length.

Stay connected with us on social media platform for instant update click here to join our  Twitter, & Facebook

We are now on Telegram. Click here to join our channel (@TechiUpdate) and stay updated with the latest Technology headlines.

For all the latest Health News Click Here 

 For the latest news and updates, follow us on Google News

Read original article here

Denial of responsibility! NewsAzi is an automatic aggregator around the global media. All the content are available free on Internet. We have just arranged it in one platform for educational purpose only. In each content, the hyperlink to the primary source is specified. All trademarks belong to their rightful owners, all materials to their authors. If you are the owner of the content and do not want us to publish your materials on our website, please contact us by email – [email protected]. The content will be deleted within 24 hours.