Replication

University of Pittsburgh researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells. Published today in the…

In a twist on the question, "Which came first, the chicken or the egg?," scientists have long faced a similar question about how human adenovirus replicates: "Which comes first, assembly of the viral particle, or packaging of the viral…

Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of…

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome -- a cell's complete set of DNA -- is most vulnerable while it is being duplicated before a cell divides. Cancer cells…

A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that's critical for successful viral replication. The finding, published in Nature, could lead to…

Coinfection of SARS-CoV-2 and influenza A virus changes neither the trajectory, nor the severity of influenza A virus, regardless of timing. But should the host contract influenza A virus first, the response to that infection can…

By Amol Agrawal The Reserve Bank of India (RBI) released the report of the Regulatory Review Authority (RRA 2.0) recently. RBI had set up RRA in 2021 to ‘reduce the compliance burden on Regulated Entities (REs) by streamlining the…

Repurposed drugs may have a speedier path to clinical use because they have already been shown to be safe in people. A study publishing May 19in the open access journal PLOS Pathogens by Sandrine Belouzard and Jean Dubuisson at Pasteur…

When cells reproduce, the internal mechanisms that copy DNA get it right nearly every time. Rice University bioscientists have uncovered a tiny detail that helps us understand how the process could go wrong. Their study of enzymes revealed…

The function of an enzyme, critical to most forms of life, has been revealed. A research team, led by the John Innes Centre found that the enzyme DNA topoisomerase VI (topo VI) performs a critical role in removing chromosome tangles that…