Androgen

The androgen receptor is a key transcriptional factor for the proper sex development -- specially in males -- and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several…

New insights into the effects of a hormonal treatment for transgender men, discovered by Cedars-Sinai investigators, could have implications for the treatment of breast cancer. Transgender men who were assigned female at birth and identify…

Prostate cancer is the most common cancer among men in the United States. Many patients can live long lives due to early detection and treatment with androgen deprivation therapy. However, despite the benefits of this therapy, almost all…

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature. The…

A majority of patients with previously treated androgen receptor (AR)-expressing salivary gland cancer (SGC) achieved disease control with…

Androgen Receptor (AR) inhibition is an important therapeutic approach for the treatment of Castration-Resistant Prostate Cancer (CRPC), but AR-escape mechanisms related to the expression of AR splice variants (AR-SV), such as AR-V7,…

--Sabizabulin is a novel oral androgen receptor transport disruptor---- In Phase 1b/2 clinical study, sabizabulin was well tolerated with significant antitumor efficacy in metastatic castration resistant prostate cancer patients who have…

As the disproportionate number of men who were hospitalized with COVID-19 presented with androgenetic alopecia (a common form of hair-loss) compared to the expected number in a similar age-matched population (79% vs. 31-53%), the team…