Histology of Vaccine Myocarditis; PFO Closure for Divers; New Evolut Valve OK’d

Young people with low levels of physical activity were found to be at increased risk of stroke if they clocked in 8 or more hours of sedentary time per day. (Stroke)

Mavacamten priced at $75,000 per year would be less cost-effective than myectomy and septal ablation for hypertrophic cardiomyopathy patients, a draft ICER report found.

In vaccine-induced immune thrombotic thrombocytopenia associated with the AstraZeneca COVID-19 vaccine, the thrombus formation is accompanied by activation of neutrophils and various immune pathways. (European Heart Journal)

Two cases of histologically confirmed myocarditis after COVID mRNA vaccination: one on endomyocardial biopsy and the other from autopsy. (New England Journal of Medicine)

The American Heart Association (AHA) urged more research on identifying and managing opioid use disorder in people with cardiovascular disease. (Circulation)

Approximately 1% to 6% of children and adolescents have obstructive sleep apnea. Whether this condition alone predisposes them to hypertension remains to be seen, the AHA said. (Journal of the American Heart Association)

Registry data showed that outpatient prescribing practices for PCSK9 inhibitors varied widely by race, geography, and practice across the U.S. as late as 2019. (Circulation: Cardiovascular Quality and Outcomes)

Elderly people with heart failure saw quality-of-life benefits from left ventricular assist devices, INTERMACS registry data suggested. (Journal of the American College of Cardiology)

Composition of gut bacteria plays a part in the relationship between flavonoid-rich foods (e.g., fruits, vegetables, tea, chocolate, red wine) and lower blood pressure. (Hypertension)

Patients with a low burden of paroxysmal atrial fibrillation could have that burden reduced further in the year following catheter ablation, along with improved quality of life, according to a secondary analysis of CIRCA-DOSE. (JAMA Cardiology)

Divers who received patent foramen ovale closure had no incident decompression sickness over the next 6.5 years on average. (JACC: Cardiovascular Imaging)

Remote ischemic conditioning, offered in cycles of blood pressure cuff inflation, flunked out as a way to reduce reperfusion injury during primary percutaneous coronary intervention for ST-segment elevation MI. (Heart)

A rare case of late clinical leaflet thrombosis occurred 1.5 years after transcatheter aortic valve replacement (TAVR), despite clopidogrel (Plavix) and edoxaban (Savaysa) therapy. (JACC: Case Reports)

FDA approved the fourth-generation Evolut FX from Medtronic’s lineup of TAVR systems. This device received gold marks for direct visualization, a redesigned catheter tip, and a more flexible delivery system, Medtronic said.

Janssen announced that rivaroxaban (Xarelto) now has an expanded indication from the FDA for peripheral artery disease patients fresh out of lower-extremity revascularization.

The agency also cleared the CardioNXT iMap 3D mapping system for use in patients with cardiac arrhythmias, the manufacturer said.

An algorithm based on remote monitoring data was able to predict two-thirds of post-implant heart failure hospitalizations, Biotronik announced.

A selective serotonin reuptake inhibitor bested exercise for the treatment of anxiety in patients with coronary heart disease, a small randomized trial showed. (JAMA Psychiatry)

Immigrants to Canada had a 33% lower stroke rate than long-term residents. (Neurology)

Can the antiplatelet sarpogrelate (Anplag) stop cardiac hypertrophy in its tracks? The AHA highlights a mouse study that suggests so.