PD-1 Non-Small Cell Lung Cancer Clinical Trials Pipeline Analysis: 20+ Companies are Working to Improve the Treatment Space | DelveInsight

New York, USA, June 20, 2023 (GLOBE NEWSWIRE) — PD-1 Non-Small Cell Lung Cancer Clinical Trials Pipeline Analysis: 20+ Companies are Working to Improve the Treatment Space | DelveInsight

The prevalence of non-small cell lung cancer has been rising over the past few years, which prompts a growing demand for treatment options. The introduction of PD-1 cancer vaccines in non-small cell lung cancer with fewer side effects and increasing funding and government support towards the development of new drugs would drive the market of PD-1 cancer vaccines. The companies developing the potential therapies in the late stage of development include Summit Therapeutics, Arcus Biosciences, GlaxoSmithKline, and several others.

DelveInsight’s ‘PD-1 Non-Small Cell Lung Cancer Pipeline Insight 2023‘ report provides comprehensive global coverage of pipeline PD-1 non-small cell lung cancer therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the PD-1 non-small cell lung cancer pipeline domain.

Key Takeaways from the PD-1 Non-Small Cell Lung Cancer Pipeline Report

• DelveInsight’s PD-1 non-small cell lung cancer pipeline report depicts a robust space with 20+ active players working to develop 22+ pipeline therapies for PD-1 non-small cell lung cancer treatment. 
• Key PD-1 non-small cell lung cancer companies such as Summit Therapeutics, Arcus Biosciences, GlaxoSmithKline, Pfizer, AstraZeneca, Seagen, MacroGenics, Roche, Qilu Pharmaceutical, Shandong New Age Pharmaceutical, Symphogen, and others are evaluating new PD-1 non-small cell lung cancer drugs to improve the treatment landscape.
• Promising PD-1 non-small cell lung cancer pipeline therapies such as Ivonescimab, Zimberelimab, Dostarlimab, Sasanlimab, Rilvegostomig, SGN-PDL1V, Lorigerlimab, RO 7247669, QL1706, F520, Sym021, and others are under different phases of PD-1 non-small cell lung cancer clinical trials.
• In June 2023, Qilu Pharmaceutical presented trials in Progress poster presentation on QL1706 (iparomlimab/tuvonralimab), an innovative bifunctional antibody for immunotherapy, in two Phase III non-small cell lung carcinoma (NSCLC) clinical studies at the 2023 American Society of Clinical Oncology Annual Meeting (ASCO 2023).
• In May 2023, Summit Therapeutics announced that the first United States-based patient has been enrolled in the Phase III HARMONi study. HARMONi is a Phase III multiregional, randomized, double-blinded study. The study will evaluate the efficacy and safety of ivonescimab combined with chemotherapy in patients with epidermal growth factor receptor (EGFR)-mutated, locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who have progressed after treatment with a third-generation EGFR tyrosine kinase inhibitor (TKI) such as osimertinib.
• In May 2023, Gilead Sciences and Arcus Biosciences announced updated results from an interim analysis of the ARC-7 study in patients with first-line, metastatic non-small cell lung cancer (NSCLC) with PD-L1 tumor proportion score (TPS) 50% without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutations. Progression-free survival curves showed early separation of both domvanalimab-containing arms from the zimberelimab arm, which was consistently maintained, and supports the potential therapeutic benefit of inhibiting the TIGIT pathway.
• In October 2022,  Akeso Biopharma announced that the Center for Drug Evaluation (CDE) of the China National Medical Products Administration (NMPA) granted Breakthrough Therapy Designation (BTD) for Ivonescimab (PD-1/VEGF bispecific antibody, AK112) combined with docetaxel for the treatment of locally advanced or metastatic Non-Small-Cell Lung Carcinoma (NSCLC) patients who failed to respond to prior PD-(L)1 inhibitor combined with platinum-based doublet chemotherapy.
• In October 2022, GSK announced positive headline results from PERLA, the phase II trial of Jemperli (dostarlimab) plus chemotherapy in patients with metastatic non-squamous non-small cell lung cancer. The safety and tolerability profile of dostarlimab in the PERLA phase II trial was consistent with previous clinical trials of similar regimens. The most common treatment-emergent adverse reactions were anemia, asthenia, nausea, constipation, cough, dyspnoea, vomiting, decreased appetite, and neutropenia.

Request a sample and discover the recent advances in PD-1 non-small cell lung cancer treatment drugs @ PD-1 Non-Small Cell Lung Cancer Pipeline Report

The PD-1 non-small cell lung cancer pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage PD-1 non-small cell lung cancer drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the PD-1 non-small cell lung cancer clinical trial landscape.

PD-1 Non-Small Cell Lung Cancer Overview

Lung cancer is a cancer that begins in the lungs. Cancer develops when cells in the body begin to proliferate uncontrollably. Non-Small Cell Lung Cancer accounts for 80% to 85% of all lung cancers. Non-Small Cell Lung Cancer is classified into three subtypes: adenocarcinoma, squamous cell carcinoma, and big cell carcinoma. Because their treatment and prognosis are typically similar, these subtypes, which begin in distinct types of lung cells, are classed together as Non-Small Cell Lung Cancer.

Some persons with non-small cell lung cancer can be treated with drugs that target these checkpoints. Immunotherapies targeting programmed death ligand 1 (PD-L1) and its receptor (PD-1) have increased survival in a subset of advanced lung cancer patients. PD-L1 protein expression has emerged as a biomarker for predicting which individuals may respond better to immunotherapy. The history of using several immunohistochemistry platforms with different PD-L1 antibodies, scoring systems, and positivity cut-offs for immunotherapy clinical trials with distinct anti-PD-L1 and anti-PD-1 medicines complicates the understanding of PD-L1 as a biomarker.

Find out more about PD-1 non-small cell lung cancer treatment drugs @ Drugs for PD-1 Non-Small Cell Lung Cancer Treatment

A snapshot of the PD-1 Non-Small Cell Lung Cancer Pipeline Drugs mentioned in the report:

Learn more about the emerging PD-1 non-small cell lung cancer pipeline therapies @ PD-1 Non-Small Cell Lung Cancer Clinical Trials

PD-1 Non-Small Cell Lung Cancer Therapeutics Assessment

The PD-1 non-small cell lung cancer pipeline report proffers an integral view of the PD-1 non-small cell lung cancer emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration.

Scope of the PD-1 Non-Small Cell Lung Cancer Pipeline Report 

• Coverage: Global 
• Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Therapeutics Assessment By Route of Administration: Intravenous, Subcutaneous, Oral, Intramuscular
• Therapeutics Assessment By Molecule Type: Monoclonal antibody, Small molecule, Peptide
• Therapeutics Assessment By Mechanism of Action: Antibody-dependent cell cytotoxicity, Programmed cell death-1 receptor antagonists, Mitosis inhibitors, Tubulin polymerization inhibitors, Immunostimulants, Cell death stimulants, TIGIT protein inhibitors, Vascular endothelial growth factor receptor antagonists, T lymphocyte stimulants
• Key PD-1 Non-Small Cell Lung Cancer Companies: Summit Therapeutics, Arcus Biosciences, GlaxoSmithKline, Pfizer, AstraZeneca, Seagen, MacroGenics, Roche, Qilu Pharmaceutical, Shandong New age Pharmaceutical, Symphogen, and others
• Key PD-1 Non-Small Cell Lung Cancer Pipeline Therapies: Ivonescimab, Zimberelimab, Dostarlimab, Sasanlimab, Rilvegostomig, SGN-PDL1V, Lorigerlimab, RO 7247669, QL1706, F520, Sym021, and others

Dive deep into rich insights for new drugs for PD-1 non-small cell lung cancer treatment, visit @ PD-1 Non-Small Cell Lung Cancer Drugs

Table of Contents

For further information on the PD-1 non-small cell lung cancer pipeline therapeutics, reach out @ PD-1 Non-Small Cell Lung Cancer Treatment Drugs

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